{"id":855,"date":"2025-06-08T11:50:55","date_gmt":"2025-06-08T11:50:55","guid":{"rendered":"https:\/\/demo.bravisthemes.com\/patholab\/blood-protein-signatures-change-across-lifespan-copy\/"},"modified":"2025-06-18T08:20:34","modified_gmt":"2025-06-18T08:20:34","slug":"international-symposium-on-macromolecular-bioscience-and-biomaterials","status":"publish","type":"post","link":"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/","title":{"rendered":"International Symposium on Macromolecular Bioscience and Biomaterials"},"content":{"rendered":"\t\t
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We are excited to invite you to the International Symposium on Macromolecular Science and Biomaterials taking place on July 6-9, 2025, at the \u201cScuderie Aldobrandini Museum\u201d in Frascati.<\/p>

The symposium will feature eight keynote speakers, and opportunities for oral presentations from the participants of the Marie Sk\u0142odowska-Curie Research
and Innovation Staff Exchange programs PEPSA-MATE and BIOCOCOMER, funded by the
European Union\u2019s Horizon 2020 and Horizon Europe Research and Innovation programmes.<\/p>

The goal of this Symposium is to gather scholars from all over the world to present advances in the fields of biomacromolecule-based nanomaterials, drug delivery
and tissue engineering and to foster an environment conducive to exchanging ideas and information.
This Symposium will also provide an ideal environment to engage with long-term collaborators
and develop new international and multidisciplinary collaborations with peers and young researchers.<\/p>\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\r\n \r\n \r\n Download the complete program <\/span>\r\n <\/a>\r\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t <\/div>\r\n <\/div>\r\n \t\t\t<\/div>\n\t\t<\/section>\n\t\t
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FRANCESCA CAVALIERI<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Rome \u201cTor Vergata\u201d<\/strong>
\nAn overview of PEPSA-MATE and BIOCOCOMER MSCA EU Projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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Keynote speakers<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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BRUNO DE GEEST <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Ghent University<\/strong>
\nTumor acidosis targeted delivery of immunotherapy by Marker-Agnostic Tumor-Anchoring Chimeras<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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LORENZO ALBERTAZZI<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Eindhoven University <\/strong>
\n\nSuper-resolution imaging of nanomaterials.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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JIWEI CUI <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Shandong University <\/strong>
\nCircumvention of Biological Barriers for Improved Therapeutic Delivery.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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PAOLA LUCIANI<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Bern<\/strong>
\n Bioderived and bioinspired drug delivery systems. <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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LORENZO DI MICHELE <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Cambridge<\/strong>
Genetically encoded designer RNA condensates and organelles.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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NEVENA TODOROVA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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RMIT University<\/strong>
Interfacial Interactions Enhancing Biomaterial Stability.
\n\nInsights from Molecular Modelling<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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ANDREAS FERY <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Leibniz Institut f\u00fcr Polymerforschung Dresden <\/strong>
\n From Hairy Particles to Particle-based Metamaterials<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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Invited speakers<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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MARGHERITA MORPURGO<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Padova <\/strong>
\nThe Avidin-Nucleic Acids interaction. investigation on the molecular bases.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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MANUEL BANOBRE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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International Iberian Nanotechnology Laboratory, Portugal <\/strong>
\nA targetless theranostic strategy for precise combinatorial treatment of solid tumors using smart magnetic nanocomposites<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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MARIA KITSARA <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Bioemtech <\/strong>
\nRadio-theranostics. combining targeted radiopharmaceuticals and molecular imaging in preclinical studies.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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FRANK CARUSO <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The University of Melbourne<\/strong>
\n Nanoparticle Engineering for Organ Deposition.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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GIANCARLO FORTE <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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King\u2019s College London <\/strong>
The different layers of pathological mechanosensing.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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SORAIA FERNANDES<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The University of Melbourne <\/strong>
Antibody-Free Glycogen Nanoparticles Engage Human Immune T Cells for Intracellular Delivery of Small Drugs or mRNA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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MARIET WIUM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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International Centre for Genetic Engineering and Biotechnology, Cape Town<\/strong>
|\nThe role Axl tyrosine kinase in Cancer resistance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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VER\u00d3NICA SALGUEIRI\u00d1O <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Vigo <\/strong>
Manipulation and guiding of magnetic biodevices<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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PIETRO MATRICARDI <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Rome La Sapienza <\/strong>
Polysaccharide nanohydrogels and drug delivery. an effective combination<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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SUKHVIR KAUR BHANGU <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The University of Melbourne<\/strong>
Machine Learning for Antimicrobial Peptide Discovery. Advancing AI-Driven Drug Innovation.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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NITIN MANTRI <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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RMIT University<\/strong>
Hyaluronic Acid-Based Nanohydrogel as Effective Carrier for Transdermal Delivery of CBD for Melanoma Cancer Therapy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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QUINN BESFORD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Leibniz Institut f\u00fcr Polymerforschung Dresden <\/strong>
Exerting Control over Biomolecular Corona Formation at the Nano-Bio Interface<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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NOEMI FIASCHINI <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Nanofaber<\/strong>
Advanced u-Sponge Platform Enabling Sustained Delivery for Rheumatic Disease Therapies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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ALESSANDRO PORCHETTA <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Rome Tor Vergata<\/strong>
Input-responsive CRISPR-Cas systems for sensing applications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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MIRIAM QUATTROCIOCCHI <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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University of Rome Tor Vergata <\/strong>
DNA-based dimerization Networks. <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HILDA GARAY PEREZ<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Center for Genetic Engineering and Biotechnology<\/strong>
CIGB-552. Development of an anticancer peptide candidate from research to the clinic.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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NADIIA DAVYDIUK <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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Leibniz Institut f\u00fcr Polymerforschung<\/strong>
Dresden \nGlycogen Nanoparticles for Thrombolytic Therapy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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WENDEL ALVES <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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UFABC University <\/strong>
\nConductive Microneedle Platforms for Electrochemical Biosensing Applications.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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EMANUELA GATTO <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Splastica<\/strong>
\nInnovation and Female Leadership. The Role of Women Researchers in Shaping the Future.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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CHAN-JIN KIM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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Gyeongsang National University<\/strong>
Supramolecular Assembly of Macroscopic Functional Building Blocks via Organic\u2013Inorganic Networks<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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GERARDO ENRIQUE GUILLEN NIETO <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Center for Genetic Engineering and Biotechnology <\/strong>
\nFormulation strategies to enhance the immunogenicity of the therapeutic vaccine \"HeberNasvac\" against chronic hepatitis B.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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MUTHUPANDIAN ASHOKKUMAR <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

The University of Melbourne <\/strong>
Ultrasonics in Bioprocessing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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MARCO LATTUADA <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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Fribourg University<\/strong>
\nUsing Molecular Dynamics simulations to predict surfactants micellization and micelles-drug interactions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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DOMITILLA VANNI <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Novo Nordisk Foundation<\/strong>
\nEngineering Microbes for Health. Innovative Solutions for Diverse Diseases<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

GAETANO BARBATO<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Innosol<\/strong>
High frequency ultrasound impact on drug loaded nanoparticles release kinetics.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

BEN McLEAN <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

RMIT University<\/strong>
\nComputational insights into self-assembly and modulation of biomaterial properties<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t
\t\t<\/div>\r\n\t\t
\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

TOPICS
\n\u2022 Drug delivery and Theranostics
\n\u2022 Tissue Engineering
\n\u2022 Biomacromolecule-based nanomaterials
\n\u2022 Colloids, Interfaces and Ultrasonic Technologies<\/p>\n","protected":false},"author":1,"featured_media":12451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62],"tags":[],"class_list":["post-855","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events"],"yoast_head":"\nInternational Symposium on Macromolecular Bioscience and Biomaterials - BIOCOCOMER<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"International Symposium on Macromolecular Bioscience and Biomaterials - BIOCOCOMER\" \/>\n<meta property=\"og:description\" content=\"TOPICS \u2022 Drug delivery and Theranostics \u2022 Tissue Engineering \u2022 Biomacromolecule-based nanomaterials \u2022 Colloids, Interfaces and Ultrasonic Technologies\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/\" \/>\n<meta property=\"og:site_name\" content=\"BIOCOCOMER\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-08T11:50:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-18T08:20:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cavalierilab.com\/biococomer\/wp-content\/uploads\/2025\/05\/International-Symposium-on-Macromolecular-Science-and-Biomaterials.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"750\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/www.cavalierilab.com\/biococomer\/#\/schema\/person\/ea80fad0ae37c815f9e4c329d045fc28\"},\"headline\":\"International Symposium on Macromolecular Bioscience and Biomaterials\",\"datePublished\":\"2025-06-08T11:50:55+00:00\",\"dateModified\":\"2025-06-18T08:20:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/\"},\"wordCount\":644,\"image\":{\"@id\":\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cavalierilab.com\/biococomer\/wp-content\/uploads\/2025\/05\/International-Symposium-on-Macromolecular-Science-and-Biomaterials.jpg\",\"articleSection\":[\"Events\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/\",\"url\":\"https:\/\/www.cavalierilab.com\/biococomer\/international-symposium-on-macromolecular-bioscience-and-biomaterials\/\",\"name\":\"International Symposium on Macromolecular Bioscience and Biomaterials - 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